What is Hypo-Apoptosis?
Inversely to hyper-apoptosis, hypo-apoptosis means too little apoptosis. Hypo-apoptosis occurs when damaged cells don't perform the necessary steps for apoptosis to occur. This will lead to tumor formation or the spread of genetic anomalies.
Common Diseases
This is an incomplete list of some of some of the most common diseases that are caused my hypo-apoptosis. If the condition that you have been diagnosed with isn't on this list but your doctor explained that it is caused by hyper-apoptosis, this page may still have useful information regarding the pathophysiology behind similar disease.
Cancer
Cancer is the most common example of defective apoptosis. Malignant tumors are caused by a diseased cell replicating through mitosis where the cell forms two new cells from itself. Apoptosis is designed to destroy the cell before it can multiply and spread the diseased genetic code. When this doesn't happen, a tumor will grow. Even with defective apoptosis in one area, other areas can maintain healthy cellular growth, but a lack of apoptosis in surrounding tissue or all tissue can cause metastasis of the cancer.
ALPS
Autoimmune Lymphoproliferative Syndrome (ALPS) is a rare genetic condition that is caused by reduced apoptosis of diseased lymphocytes.
This condition also includes several other diseases such as hemolytic anemia, immune-mediated thrombocytopenia, and autoimmune neutropenia which are all apoptosis related complications of ALPS where the apoptosis spreads to red blood cells or other white blood cells.
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